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Welcome to the Mangone Lab
The mRNA molecule is the key intermediate of this process, as it is a perfect copy of the information contained in DNA, and instructs its temporal and spatial expression – producing proteins, shaping organs, timing development, and regulating biological processes in living organisms.
RNA transcription has been studied for more than half a century, focusing mainly on the initiation and elongation processes. We still do not understand, however, the mechanisms of transcriptional termination, preparation of 3’ mRNA ends, or the regulation of these sequences that in turn control gene expression at a post-transcriptional level.
The goal of my laboratory is to highlight these fundamental biological mechanisms using a systems biology approach, taking advantage of biochemistry, high-throughput genomics and the powerful genetics provided by the round worm C. elegans and human cell lines.